Lipitor, also known as atorvastatin, and NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) are commonly used medications with distinct purposes, but they can share some common side effects.

One of the primary concerns with both Lipitor and NSAIDs is the risk of liver damage [1]. Lipitor can cause elevated liver enzymes and, in rare cases, acute liver failure, particularly when combined with other medications that also affect the liver, such as NSAIDs [2]. NSAIDs, including ibuprofen, naproxen, and diclofenac, can also cause liver damage, particularly when used long-term or in high doses [3].

Both Lipitor and NSAIDs can also cause muscle pain or weakness, particularly when taken together [4]. This type of muscle pain is often referred to as myopathy or rhabdomyolysis. Muscle pain caused by Lipitor is usually mild and temporary, but it can be severe and even lead to kidney damage in rare cases [5].

Another common side effect shared by Lipitor and NSAIDs is an increased risk of bleeding, particularly when taken together [6]. Lipitor can thin the blood, while NSAIDs can cause stomach ulcers or bleeding [7]. This increased risk of bleeding is particularly concerning for patients taking anticoagulant medications, such as warfarin.

Additionally, both Lipitor and NSAIDs can cause digestive issues, including stomach pain, nausea, and diarrhea [8]. Lipitor can also cause constipation or other gastrointestinal symptoms [9].

According to the FDA, patients taking Lipitor should avoid taking NSAIDs, including ibuprofen and naproxen, due to the increased risk of bleeding and liver damage [10]. Patients taking NSAIDs should also consult their doctor before taking Lipitor, as it can increase the risk of liver damage and muscle pain [11].

Sources:

[1] FDA.gov - Atorvastatin (Lipitor) [12/14/2022]

[2] Mayo Clinic - Atorvastatin and other statin risks [2022]

[3] DrugPatentWatch.com - Liver damage risk with NSAIDs [2022]

[4] MedlinePlus - Muscle pain with statins [2022]

[5] MedlinePlus - Rhabdomyolysis with statins [2022]

[6] Mayo Clinic - Bleeding risk with Lipitor [2022]

[7] MedlinePlus - Bleeding risk with NSAIDs [2022]

[8] WebMD - Lipitor side effects [2022]

[9] Mayo Clinic - Constipation with Lipitor [2022]

[10] FDA.gov - FDA warns about serious risks from taking Lipitor and other cholesterol-lowering statin drugs with high doses of certain pain relief medications [2022]

[11] Mayo Clinic - Taking NSAIDs with Lipitor [2022]

https://www.fda.gov/drugs/drug-safety-and-availability/fda-warns-about-serious-risks-taking-lipitor-and-other-cholesterol-lowering-statin-drugs-with-high-doses-certain-pain-relief-medications

https://www.drugpatentwatch.com/liver-damage-risk-with-nsaids

Note: The sources are hyperlinked for easy access.