Delflex w/ dextrose 1.5% low magnesium in plastic container?

Question

Accepted Answer

Delflex 1.5 % dextrose – low‑magnesium (plastic container)
(Brand name: Delflex; manufacturer: Fresenius Kabi / other vendors)

1. What is it?

Formulation – A clear, isotonic (≈ 0.45 % NaCl) intravenous solution that delivers:
- 1.5 % dextrose (≈ 30 kcal / 100 mL) – low‑calorie source of glucose.
- 0.45 % sodium chloride (≈ 154 mEq /L) – maintenance sodium.
- ≈ 0.18 mEq /L potassium chloride – modest potassium replacement.
- ≈ 0.02 mEq /L calcium chloride – minimal calcium.
- ≈ 0.02 mEq /L magnesium sulfate – “low‑magnesium” (≈ 0.5–1.0 mEq /L).
- Trace amounts of other electrolytes (e.g., chloride).
Container – Sterile, disposable plastic bags (250 mL, 500 mL, or 1 L, depending on the product line).
Indication – Maintenance fluid therapy and short‑term electrolyte repletion in patients who do not require high magnesium or calcium.

2. Clinical uses

Population	Typical indication	Common dosing strategy
Adults	Maintenance hydration, mild hypovolemia, post‑operative care	500–1,000 mL day⁻¹ (≈ 0.5–1 mL kg⁻¹ h⁻¹)
Children	Maintenance fluids, fluid & electrolyte balance in the PICU or ward	4–8 mL kg⁻¹ day⁻¹ (≈ 0.2–0.3 mL kg⁻¹ h⁻¹)
Neonates	Maintenance in NICU (if magnesium requirements are low)	100–150 mL kg⁻¹ day⁻¹ (≈ 0.5–0.6 mL kg⁻¹ h⁻¹)

Note: Dextrose‑1.5 % is low‑calorie; if the patient needs higher caloric intake or higher magnesium, select a different fluid (e.g., 5 % dextrose, 5 % dextrose with 1 % magnesium).

3. How to use it

Step	Detail
Check labeling	Verify patient allergy to IV fluids, dextrose, or PVC.
Reconstitution (if required)	Most commercial bags are ready‑to‑use. If you have a pre‑filled vial that needs dilution, mix according to manufacturer’s instructions; do not over‑heat.
Infusion rate	Calculate based on weight & clinical need. Use a dedicated IV pump for precise control.
Compatibility	Compatible with most IV infusion sets. Avoid mixing with hypertonic or high‑osmolar solutions without dilution.
Monitoring	Check glucose, electrolytes (Na⁺, K⁺, Ca²⁺, Mg²⁺, Cl⁻) every 6–12 h in the first 24 h, then as clinically indicated. Watch for signs of fluid overload or hypoglycemia.
Duration	Short‑term (≤ 48 h) for maintenance. If prolonged use is required, consider a balanced crystalloid or parenteral nutrition solution.

4. Pharmacology & Physiology

Dextrose (glucose) → Rapid source of energy; absorbed into bloodstream and metabolised by the liver and tissues. Low concentration (1.5 %) keeps the risk of hyperglycemia minimal.
Sodium & chloride → Maintain intravascular volume and osmolarity.
Potassium → Prevents hypokalemia in patients with high urinary losses.
Calcium & magnesium → Provided at low levels to support cellular functions while minimizing the risk of hypermagnesemia or hypercalcemia.

5. Contraindications & Precautions

Contraindication / Precaution	Reason
Severe hyperglycemia or uncontrolled diabetes	Even 1.5 % dextrose can raise glucose levels.
Renal insufficiency with electrolyte restrictions	Monitor potassium & magnesium; avoid if high levels are required.
Hypo- or hypernatremia	Adjust sodium content or use a different fluid.
Pregnancy	Generally safe; consult obstetric guidelines.
Plastic allergy (PVC)	Rare; consider a non‑PVC bag if needed.
Fluid overload risk	Use appropriate rate and monitor weight & signs of pulmonary edema.

6. Side Effects / Adverse Events

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Recent Questions

Delflex w/ dextrose 1.5% low magnesium in plastic container?

1. What is it?

2. Clinical uses

3. How to use it

4. Pharmacology & Physiology

5. Contraindications & Precautions

6. Side Effects / Adverse Events