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Delflex w/ dextrose 2.5% low magnesium low calcium in plastic container?

See the DrugPatentWatch profile for Delflex

Delflex (2.5 % Dextrose Low Magnesium Low Calcium – Plastic Container)
(Brand‑specific formulation – not a generic “Delflex” available everywhere.)

1. What is Delflex?

Item Detail
Indication Isotonic IV fluid for fluid resuscitation, maintenance of electrolytes, and as a carrier for drugs in patients who need a dextrose‑containing solution with low magnesium and calcium.
Route Intravenous (IV) infusion only.
Packaging 1 L (1000 mL) or 500 mL plastic bags/bottles (polyethylene or polypropylene).
Shelf Life 24 months when stored in a cool, dry place; once opened, use within 24 h in the clinic or hospital setting.
Sterility USP‑class III, sterile, single‑use.

2. Composition (per 1 L)

Component Amount per Liter Role
Sodium chloride (NaCl) 154 mmol (0.9 %) Restores/maintains Na⁺ & Cl⁻ balance
Dextrose (D₂O) 25 g (2.5 %) Energy source & osmotic agent
Potassium chloride (KCl) 5 mmol (0.1 %) Maintains plasma K⁺
Magnesium chloride (MgCl₂) 0.1 mmol (≈ 5 mg) Low‑dose Mg supplement
Calcium chloride (CaCl₂) 0.1 mmol (≈ 5 mg) Low‑dose Ca supplement
Total osmolality 280–310 mOsm/kg Isotonic to plasma

Note: Exact concentrations can vary by manufacturer (e.g., VWR, Bausch‑Lomb). Always verify the specific label you have.

3. Typical Clinical Uses

Situation Why use Delflex?
General maintenance fluid Provides 100 mL/hr of isotonic fluid with 2.5 % dextrose.
Electrolyte repletion Supplies small, controlled amounts of K⁺, Mg²⁺, Ca²⁺ when “low‑dose” replacement is needed (e.g., after moderate renal loss).
Drug carrier Dilutes and delivers medications that require a dextrose vehicle (e.g., insulin, certain antibiotics).
Fluid resuscitation In hypovolemic patients who also need dextrose for glucose homeostasis.

4. Dosing & Administration

  1. Calculate total fluid volume needed for the patient (e.g., 100 mL/kg/day for maintenance).
  2. Infuse rate: 50–200 mL/hr is typical; adjust based on clinical status, cardiac function, and fluid tolerance.
  3. Additives: Add other IV solutions (e.g., 5 % dextrose) with caution—may cause hyperglycemia or dilutional hyponatremia.
  4. Check compatibility: Use compatibility charts to avoid precipitation when mixing with other IV drugs.
  5. Monitoring: Check electrolytes (Na⁺, K⁺, Mg²⁺, Ca²⁺) every 12–24 h; adjust dose if needed.

Example: A 70‑kg adult requiring 100 mL/kg/day of maintenance fluid would receive ~7 L/day → 3 × 1 L bags of Delflex.

5. Contraindications & Precautions

Condition Reason
Hypernatremia Adds Na⁺; can worsen high Na⁺ levels.
Hyperkalemia Contains K⁺; avoid in patients with K⁺ > 5.5 mmol/L.
Hypersensitivity to any ingredient Rare but can lead to anaphylaxis.
Renal failure with hypermagnesemia Though low Mg²⁺, cumulative effect in CKD could be problematic.
Heart failure or fluid overload Isotonic fluid may worsen pulmonary edema.

Drug Interactions

  • ACE inhibitors / ARBs / potassium‑sparing diuretics: ↑ K⁺ levels.
  • Digoxin: Hypomagnesemia can precipitate digoxin toxicity; though this formulation has low Mg, monitor anyway.
  • Lithium: Low Mg can affect lithium clearance; monitor levels.
  • Corticosteroids: May increase potassium loss → additive effect.

6. Adverse Effects

Effect Frequency Mitigation
Electrolyte imbalance Common (up to 5 % in large studies) Regular labs, adjust rates.
Hypoglycemia Rare (1–2 % when dextrose diluted) Check glucose; use with caution in diabetics.
Allergic reaction < 1 % Stop infusion, treat with antihistamines/epinephrine.
Phlebitis/infusion site irritation 1–3 % Use central line if peripheral irritation persists.
Plasticizer leaching (from plastic bag) Very rare Use FDA‑approved containers; avoid prolonged contact with high‑fat solutions.

7. Storage & Handling

Step Recommendation
Temperature 2–25 °C; avoid freezing.
Light Store in a dark place; light can degrade dextrose.
Container integrity Inspect for cracks or leaks before use.
Compatibility Avoid mixing with high‑pH solutions (e.g., bicarbonate) or highly acidic drugs that may precipitate.

8. Quick Reference (for clinicians)

Parameter Typical Value
Na⁺ 154 mmol/L
K⁺ 5 mmol/L
Cl⁻ 154 mmol/L
Mg²⁺ 0.1 mmol/L
Ca²⁺ 0.1 mmol/L
Dextrose 25 g/L


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