Lacosamide is an antiepileptic drug used to treat partial-onset seizures in adults with epilepsy. While it is an effective medication for controlling seizures, it may have some long-term effects on cardiovascular health. According to the Mayo Clinic [2], lacosamide can cause some serious side effects that may affect the heart, including changes in heart rhythm, slow heartbeat, and low blood pressure. These side effects can be more severe in patients with pre-existing heart conditions.

A study published in the journal Seizure [3] investigated the cardiovascular effects of lacosamide in patients with epilepsy. The study found that lacosamide did not have any significant effects on heart rate, blood pressure, or electrocardiogram (ECG) parameters. However, the study did note that more research is needed to determine the long-term effects of lacosamide on cardiovascular health.

Another study published in the Journal of Clinical Neurophysiology [4] found that lacosamide may increase the risk of sudden unexpected death in epilepsy (SUDEP) in patients with epilepsy. SUDEP is a rare but serious complication of epilepsy that is thought to be related to cardiac arrhythmias. The study found that patients taking lacosamide had a higher risk of SUDEP compared to patients taking other antiepileptic drugs. However, the study noted that the overall risk of SUDEP is still very low, and more research is needed to determine the exact relationship between lacosamide and SUDEP.

In conclusion, lacosamide may have some long-term effects on cardiovascular health, including changes in heart rhythm, slow heartbeat, and low blood pressure. While some studies have found that lacosamide does not have significant effects on cardiovascular health, other studies have suggested that it may increase the risk of SUDEP in patients with epilepsy. Patients taking lacosamide should be monitored closely for any signs of cardiovascular side effects, especially if they have pre-existing heart conditions.

Sources:
[2] Mayo Clinic. Lacosamide (Oral Route) - Side Effects. https://www.mayoclinic.org/drugs-supplements/lacosamide-oral-route/side-effects/drg-20072409?p=1
[3] Seizure. Cardiovascular effects of lacosamide in patients with epilepsy. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334591/
[4] Journal of Clinical Neurophysiology. Sudden Unexpected Death in Epilepsy: The Role of Antiepileptic Drugs in Prevention. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984349/