Based on the information available, there is no definitive evidence to suggest that Lipitor, a medication used to treat high cholesterol, has more severe side effects when taken in conjunction with a high-fat diet. However, it is generally recommended that patients on Lipitor or similar statin medications follow a heart-healthy diet to help manage their cholesterol levels [1].

It is important to note that Lipitor can have side effects, regardless of diet. Common side effects of Lipitor include muscle pain, digestive problems, and increased liver enzymes [2]. More serious side effects, such as muscle damage and liver problems, are less common but can occur [2].

It is always recommended to consult with a healthcare provider for personalized medical advice, as they can provide guidance based on an individual's specific health history and current medications.

In summary, while there is no direct evidence to suggest that Lipitor has more severe side effects with high fat intake, it is still recommended to follow a heart-healthy diet to help manage cholesterol levels.

Sources:

1. [DrugPatentWatch.com](https://www.drugpatentwatch.com/drugs/lipitor)
2. Mayo Clinic. (2021). Atorvastatin (Oral Route). Retrieved from <https://www.mayoclinic.org/drugs-supplements/atorvastatin-oral-route/side-effects/drg-20069851?p=1>