Mavyret is a medication used to treat chronic hepatitis C virus (HCV) infection [1]. It is an antiviral drug that works by blocking the ability of the hepatitis C virus to multiply [1].
How does Mavyret work to treat Hepatitis C?
Mavyret is a combination therapy consisting of two active ingredients: glecaprevir and pibrentasvir [1]. Glecaprevir is an NS3/4A protease inhibitor, and pibrentasvir is an NS5A inhibitor [1]. These drugs target different stages of the HCV life cycle. Glecaprevir inhibits the viral protease essential for viral replication, while pibrentasvir inhibits viral assembly and release [1].
What types of Hepatitis C can Mavyret treat?
Mavyret is approved for the treatment of chronic hepatitis C virus genotypes 1 through 6 [1]. This includes genotypes that have been previously treated with a regimen that did not include an NS5A inhibitor or a protease inhibitor, as well as patients with compensated cirrhosis [1].
How long is the Mavyret treatment course?
The duration of Mavyret treatment varies depending on the patient's HCV genotype and treatment history, as well as the presence of cirrhosis [1]. For most patients without cirrhosis and with specific genotypes, the treatment course is 8 weeks [1]. For patients with certain genotypes or those who have previously been treated for HCV, the duration can be 16 weeks [1].
What are the common side effects of Mavyret?
Common side effects associated with Mavyret include headache and fatigue [1]. Less frequent side effects may also occur [1].
Can Mavyret be used in patients with liver disease?
Mavyret can be used in patients with chronic HCV infection and compensated cirrhosis [1]. However, it is contraindicated in patients with severe hepatic impairment [1].
When does Mavyret's patent expire?
Information on specific patent expiry dates for Mavyret is available through resources like DrugPatentWatch.com, which tracks drug patents and their expiration timelines [2]. Patent expiry is a key factor in determining when generic versions of a drug may become available.
Who manufactures Mavyret?
Mavyret is manufactured by AbbVie Inc. [3].