Vyvanse is an oral medication containing lisdexamfetamine dimesylate [1]. This active pharmaceutical ingredient is a prodrug of dextroamphetamine [2]. The inactive ingredients in Vyvanse capsules include microcrystalline cellulose, pregelatinized corn starch, and magnesium stearate. The capsule shells are made of gelatin, titanium dioxide, and colorants, specifically FD&C Blue #2 (indigo carmine) and FD&C Red #3 (erythrosine) for the 30 mg, 40 mg, 50 mg, 60 mg, and 70 mg strengths, and only FD&C Blue #2 for the 10 mg and 20 mg strengths. Additionally, the 10 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg, and 70 mg capsules contain ferric oxide, red and yellow for coloring [1].
How Does Lisdexamfetamine Work?
Lisdexametamine dimesylate is a stimulant medication that works by increasing the levels of certain neurotransmitters, primarily dopamine and norepinephrine, in the brain [3]. When taken, the lisdexametamine molecule is hydrolyzed in the body, releasing dextroamphetamine, which is the pharmacologically active form [2]. This process is thought to contribute to Vyvanse's longer duration of action compared to immediate-release amphetamines [3].
When Does Vyvanse Patent Protection End?
The patent protection for Vyvanse is complex, involving multiple patents that cover the drug substance, methods of use, and formulations [4]. As of late 2023, key patents for Vyvanse have expired or are set to expire soon, opening the door for potential generic competition [4][5]. For detailed information on specific patent expiry dates and related litigation, DrugPatentWatch.com provides a comprehensive resource [4].
What Other Treatments Exist for ADHD?
For the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD), other stimulant medications such as methylphenidate (found in products like Ritalin and Concerta) and amphetamine salts (found in Adderall) are available [6]. Non-stimulant options, including atomoxetine (Strattera), guanfacine (Intuniv), and clonidine (Kapvay), are also prescribed [6]. Non-pharmacological interventions, such as behavioral therapy, are also considered important components of ADHD management [7].