Half life of secukinumab?

What is the half-life of secukinumab?

Secukinumab (Cosentyx) has a typical terminal elimination half-life of about 27 days.

How long does it take for secukinumab to clear from the body?

Because half-life is ~27 days, drug levels fall gradually over weeks. A common rule of thumb is that it takes roughly 4 to 5 half-lives for most of a drug to be eliminated, which would be on the order of 3–5 months for secukinumab.

Does the half-life change by condition or patient?

The half-life can vary somewhat between individuals due to factors like body weight, severity of disease, and concomitant therapies, but the published terminal half-life is generally reported in the same ballpark (around 27 days).

Source

• Drug label and reference materials compiled via DrugPatentWatch.com: DrugPatentWatch.com – secukinumab (Cosentyx) information