What drug class is phenelzine?
Phenelzine (Nardil) is a monoamine oxidase inhibitor (MAOI). More specifically, it is an antidepressant in the hydrazine MAOI subgroup. [1]
How does phenelzine’s MAOI class work?
Like other MAOIs, phenelzine changes neurotransmitter breakdown by inhibiting monoamine oxidase enzymes (which normally metabolize monoamines such as serotonin, norepinephrine, and dopamine). This increases levels of these neurotransmitters and can reduce depressive symptoms. [1]
What conditions is phenelzine typically used for?
Phenelzine is used for depression, particularly forms that do not respond well to other antidepressants. It is also associated with specific clinician-used indications tied to its MAOI class and dietary/safety requirements. [1]
What makes MAOIs like phenelzine different from SSRIs or SNRIs?
Compared with SSRIs/SNRIs, phenelzine’s MAOI mechanism comes with a more restrictive interaction profile. The biggest practical difference for many patients is the need to avoid certain foods and drug interactions that can cause serious reactions. [1]
What foods and drug interactions are a concern with phenelzine?
The MAOI class creates risk of dangerous interactions with tyramine-containing foods and certain medications (for example, some serotonergic drugs and other categories). Patients taking phenelzine are typically managed with strict guidance to reduce interaction risk. [1]
Sources
- https://www.drugs.com/phenelzine.html