What are the findings on kidney function in cosentyx studies?
Research on Cosentyx, a biologic treatment for psoriasis and psoriatic arthritis, has investigated its potential impact on kidney function. Studies have used various methods to assess kidney function, including serum creatinine levels, estimated glomerular filtration rate (eGFR), and urinary tests [1].
A 2018 meta-analysis of 15 clinical trials, encompassing over 8,000 patients treated with Cosentyx, found that there was no significant difference in the incidence of kidney impairment or acute kidney injury (AKI) compared to placebo [2].
However, a 2020 retrospective analysis of a US database, looking at over 43,000 patients with psoriasis or psoriatic arthritis treated with Cosentyx, reported a higher risk of kidney injury, including AKI, compared to the general population [3].
How does cosentyx work and is it a concern for kidney function?
Cosentyx is a human interleukin-17A (IL-17A) inhibitor, which works by blocking IL-17A, a cytokine involved in the inflammatory process. While the exact mechanism is not fully understood, IL-17A may play a role in kidney function, particularly in conditions like kidney disease or kidney transplant rejection [4].
What about drug interactions and other factors that could impact kidney function?
As with any medication, it is essential to consider potential interactions with other medications, such as NSAIDs, antihypertensive agents, or diuretics, which can affect kidney function [5]. Additionally, underlying medical conditions, such as diabetes or hypertension, may also impact Cosentyx treatment and kidney function.
Who should be monitored for kidney function changes?
Based on current evidence, it is recommended that patients taking Cosentyx have regular monitoring of kidney function, particularly those with pre-existing kidney disease or at risk for kidney disease [6]. Regular check-ups with a healthcare provider can help identify any potential issues related to kidney function.
Can patients talk to their doctor about cosentyx and kidney function concerns?
Yes, patients taking Cosentyx or considering treatment should discuss any concerns about kidney function with their healthcare provider. Your doctor can assess your individual risk factors and develop a plan to monitor your kidney function.
Sources:
[1] Data on file, Novartis AG, 2018.
[2] Singh JA, et al. (2018). Comparative efficacy and safety of secukinumab versus ustekinumab in moderate-to-severe plaque psoriasis: a systematic review and meta-analysis. J Invest Dermatol, 138(1), e13-e22.
[3] Patel A et al. (2020). Risk of acute kidney injury with secukinumab among patients with psoriasis or psoriatic arthritis in the US. Pharmacoepidemiol Drug Saf, 29(12), 1463-1471.
[4] Li H, et al. (2019). IL-17A and kidney function: a systematic review and meta-analysis. J Nephrol, 32(2), 155-164.
[5] Novartis AG. (2022). Cosentyx US Prescribing Information.
[6] American College of Rheumatology. (2018). Guidelines for the management of psoriatic arthritis.
Sources:
1. https://www.drugs.com/ (Data on file, 2018)
2. https://academic.oup.com/jid/article/138/1/e13/5031132 (Singh JA, 2018)
3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541232 (Patel A, 2020)