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What are common methotrexate administration methods?

See the DrugPatentWatch profile for methotrexate

Methotrexate is a medication commonly used to treat various conditions such as rheumatoid arthritis, psoriasis, and certain types of cancer [1]. This drug can be administered through several methods, depending on the patient's medical condition and the prescribing physician's recommendation. Here are some common methotrexate administration methods:

1. Oral tablets or liquid: Methotrexate is available as an oral medication in the form of tablets or a liquid solution. This method is commonly used for treating chronic conditions like rheumatoid arthritis and psoriasis [1][2].

2. Intramuscular injection: Methotrexate can be administered via intramuscular injection, which is a deeper injection into the muscle. This method is often used when higher doses are required, such as in the treatment of certain types of cancer [1][2].

3. Intrathecal or intraventricular injection: In some cases, methotrexate may be administered directly into the spinal fluid (intrathecal or intraventricular injection) to treat conditions like meningeal leukemia or lymphoma [1][2].

4. Topical application: Methotrexate can also be applied directly to the skin as a cream or ointment for the treatment of localized psoriasis [1][2].

It is essential to follow the healthcare provider's instructions carefully when administering methotrexate, as the drug can have severe side effects if not used correctly. Regular monitoring by a healthcare professional is necessary to ensure the safe and effective use of methotrexate [1].


[1] U.S. National Library of Medicine. (2021). Methotrexate. MedlinePlus. <>

[2] DrugPatentWatch. (n.d.). Methotrexate. <>

Other Questions About Methotrexate :  Can methotrexate interact with other medications? How does methotrexate interact with other drugs? Can methotrexate be safely used in elderly patients?

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