Propofol is widely known by its brand name Diprivan [1]. Other common brand names for propofol include Generic Propofol and Propofol-Lipuro [2].
Who manufactures Diprivan?
The original developer and marketer of Diprivan was AstraZeneca [3]. However, the marketing and distribution rights have changed hands over time. Currently, Fresenius Kabi is a significant manufacturer of propofol products in the United States, including generic versions and branded formulations like Propofol-IP [4][5].
When did propofol become available?
Propofol was first introduced to the market in the United Kingdom in 1986 [6]. It received FDA approval in the United States in December 1989 [7].
What are the different formulations of propofol?
Propofol is available in various formulations. One notable formulation is Propofol-Lipuro, which is a lipid emulsion containing soybean oil, medium-chain triglycerides, and glycerol [2]. Generic propofol emulsions are also widely available [5].
Why is propofol used?
Propofol is a short-acting intravenous anesthetic agent used for the induction and maintenance of anesthesia and sedation for procedures such as mechanical ventilation [1][7]. Its rapid onset and short duration of action make it suitable for these applications [1].
What are the risks associated with propofol use?
While propofol is generally safe when administered by trained professionals, it carries risks. One significant concern is Propofol Infusion Syndrome (PRIS), a rare but potentially fatal condition associated with prolonged high-dose infusions [8]. PRIS can manifest with symptoms such as metabolic acidosis, rhabdomyolysis, hyperkalemia, cardiac failure, and renal failure [8]. Other potential side effects include respiratory depression, hypotension, and injection site pain [1][7].