See the DrugPatentWatch profile for flexeril
Can you take Flexeril (cyclobenzaprine) with Advil (ibuprofen)?
In general, Flexeril (cyclobenzaprine) and Advil (ibuprofen) can be taken together because they don’t have a known direct drug-drug interaction. They work in different ways: Flexeril helps with muscle spasm, while Advil reduces pain and inflammation.
What precautions should you take if you combine them?
Even without a direct interaction, safety depends on your health history and other meds:
Flexeril can cause drowsiness, dizziness, and slowed reaction time. Avoid alcohol and be careful with driving or operating machinery until you know how you respond.
Advil (ibuprofen) can irritate the stomach and raise bleeding risk in some people. Avoid or be cautious if you have a history of stomach ulcers/GI bleeding, kidney disease, or you take blood thinners (like warfarin), antiplatelet drugs (like clopidogrel), or other NSAIDs.
If you have heart disease or uncontrolled high blood pressure, ask a clinician before using ibuprofen regularly.
What side effects might look like a problem (and when to stop)?
Stop and get urgent medical help if you develop signs of an allergic reaction (swelling of face/lips, trouble breathing), severe dizziness/fainting, or unusual bleeding or black/tarry stools (a GI bleed sign).
Contact a clinician promptly if you get severe stomach pain, vomiting blood, new or worsening confusion, or extreme sleepiness.
Does it matter how long you’re taking them?
Yes. Short-term, as-directed use is usually the scenario when people combine a muscle relaxant with an NSAID. Long-term or frequent ibuprofen use increases stomach, kidney, and cardiovascular risks, so it should be guided by a clinician.
Who should ask first before using Advil with Flexeril?
Check with a clinician or pharmacist first if you:
- Are older (higher risk of side effects)
- Have kidney disease, a history of ulcers, or prior GI bleeding
- Take blood thinners or multiple pain medicines
- Have glaucoma, urinary retention/prostate issues, or certain heart rhythm problems (Flexeril can be an issue in some people)
Are there any situations where you should not take Flexeril at the same time?
Flexeril should be avoided or used only with guidance if you’ve had certain heart rhythm issues, or if you’re taking other medications that strongly increase sedation or affect the same brain pathways (for example, some antidepressants or other sedating drugs). A pharmacist can quickly review your medication list.
If you tell me your age, the Flexeril dose you have (5 mg/10 mg/etc.), how many days you plan to take it, and any other meds/health conditions (especially stomach/kidney issues or blood thinners), I can help you gauge the risk more specifically.