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How common is muscle pain with Lipitor? Muscle pain, or myalgia, occurs in roughly 3–5% of patients taking atorvastatin, the active ingredient in Lipitor. This rate matches the placebo rate in most trials, so many cases may not be caused by the drug itself. How does Lipitor muscle pain compare with other statins? Atorvastatin shows similar rates of muscle pain to simvastatin and rosuvastatin. Higher doses of any statin tend to increase risk, especially when combined with certain drugs that raise blood levels of the active ingredient. What happens if muscle pain develops on Lipitor? Doctors usually pause the statin temporarily to see if symptoms resolve. If they do, they can restart at a lower dose or switch to a different statin or non-statin cholesterol drug. Most patients who experience myalgia can still take a statin after these adjustments. When does Lipitor muscle pain usually start? Symptoms can appear weeks to months after starting or after a dose increase. Patients are advised to report any unexplained muscle pain, weakness, or tenderness right away. How serious can Lipitor muscle pain be? Rarely, statins trigger rhabdomyolysis, a severe breakdown of muscle tissue that releases into the blood and harms the kidneys. This occurs at rates of about 1 in 10,000 to 1 in 100,000 per year.
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