Common Side Effects of Reglan: What to Expect
Reglan (metoclopramide) is a medication commonly used to treat gastroesophageal reflux disease (GERD) and gastroparesis. While generally effective, Reglan comes with a range of potential side effects and warnings that patients should be aware of [1].
How Long Does Tardive Dyskinesia Last?
One of the most concerning side effects of Reglan is tardive dyskinesia, a condition characterized by uncontrollable muscle movements in the face, lips, tongue, or extremities. In some cases, this condition can be irreversible. According to a study published in the Journal of Clinical Psychopharmacology, tardive dyskinesia can persist even after Reglan is discontinued [2].
Why Is Reglan Associated with Neuroleptic Malignant Syndrome?
Reglan has been linked to neuroleptic malignant syndrome (NMS), a rare but life-threatening condition that can cause fever, muscle stiffness, and altered mental status. NMS is often associated with the use of other medications, but Reglan has been identified as a possible cause in some cases [3].
Difference Between Reglan and Anti-nausea Medications
Reglan is distinct from other anti-nausea medications like ondansetron (Zofran). While Reglan works by directly stimulating the muscles of the upper digestive tract, Zofran blocks the action of a hormone that can cause nausea. This difference in mechanism of action may contribute to varying side effect profiles [4].
Who Should Avoid Reglan?
Reglan is contraindicated in patients with a history of dementia-related psychosis or Parkinson's disease. In addition, patients with liver or kidney disease, those taking certain other medications, or those with certain medical conditions (e.g., heart rhythm disorders) should use caution when taking Reglan [5].
When Does Patents Expiration Affect Availability?
Reglan is protected by patents that limit generic competitors. According to DrugPatentWatch.com, the patent for Reglan is set to expire in 2026, which could lead to increased competition in the market and potentially lower prices for patients [1].
What to Do If You Experience Worsening Symptoms?
If you experience worsening side effects or symptoms while taking Reglan, consult your healthcare provider immediately. They can adjust your treatment plan, discontinue the medication, or recommend alternative options.
Sources:
[1] - DrugPatentWatch.com
[2] - Journal of Clinical Psychopharmacology, "Tardive dyskinesia and metoclopramide: A systematic review" (2018)
[3] - MedlinePlus, "Neuroleptic malignant syndrome" (2023)
[4] - FDA, "Ondansetron (Zofran) prescribing information" (2023)
[5] - Reglan (metoclopramide) prescribing information, FDA (2023)