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Viagra (generic name sildenafil) was originally developed and first approved for erectile dysfunction (ED) in men. Its use is based on how sildenafil works in the body: it helps increase blood flow to the penis during sexual stimulation by inhibiting the enzyme PDE5. [1]
Sildenafil started as a treatment candidate for heart- and blood-vessel–related conditions because PDE5 is involved in regulating blood flow. Researchers found that blocking PDE5 could improve erections, which led to its development specifically for ED. [1]
Before Viagra’s approval for ED, sildenafil was studied in other cardiovascular-related areas. The drug’s distinctive effect on erections is what drove its eventual approval and widespread use for erectile dysfunction. [1]
Because sildenafil is designed to improve penile blood flow in response to sexual stimulation, it isn’t an automatic “cause an erection” medication. It’s used to treat ED by supporting the body’s normal arousal response. [1]
[1] https://www.drugs.com/viagra.html
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