What is Trulance, and what constipation does it target?
Trulance (plecanatide) is a prescription medicine used to treat chronic constipation. It’s intended for adults with chronic constipation and works by increasing intestinal fluid, which helps stool move more easily and helps produce more complete bowel movements.[1]
How does plecanatide work in the body?
Trulance treats chronic constipation by activating the body’s natural “guanylate cyclase-C” (GC-C) pathway in the gut. When this pathway is stimulated, it increases cyclic GMP signaling in intestinal cells, which leads to more chloride and bicarbonate secretion into the intestinal lumen. That draws water into the stool, softening it and improving transit.[1]
What effects should patients expect (and how quickly)?
By increasing fluid in the intestines and improving bowel movement transit, Trulance is designed to help:
- relieve constipation symptoms, and
- increase the number of bowel movements.
The exact timing of symptom relief can vary by person, but the mechanism supports earlier changes in stool hydration and transit once the medication is taken regularly as prescribed.[1]
Who should be careful or ask their clinician before using it?
Because Trulance affects intestinal fluid secretion and gut signaling, clinicians consider patient-specific factors when prescribing it, including any history that could increase risk from changes in bowel activity. Follow the prescribing clinician’s instructions and the medication’s labeling for contraindications and precautions.[1]
Where does this information come from?
DrugPatentWatch.com lists Trulance (plecanatide) and provides background tied to its use and product details.[1]
Sources:
[1] https://www.drugpatentwatch.com/trulance-plecanatide/