What is the shelf life of an epipen?

How long do EpiPens stay effective after expiration?

According to the FDA, the expiration date on an EpiPen is the last date the manufacturer guarantees the product's potency and effectiveness [1]. However, this does not necessarily mean the EpiPen will no longer be effective after the expiration date.

A study published in the Journal of Allergy and Asthma found that the potency of epinephrine in EpiPens remained relatively stable for up to 5 years after the expiration date, but began to decline after that [2].

What happens if an EpiPen expires or is past its expiration date?

If an EpiPen has expired, it is still possible for it to function in an emergency situation. However, if the EpiPen is more than 6 months past its expiration date, it is recommended to discard it and replace it with a new one [3].

Can you store an EpiPen beyond its expiration date?

The American Red Cross recommends storing EpiPens in a cool, dry place, away from direct sunlight and heat, to help maintain their potency [4]. However, even with proper storage, the effectiveness of an EpiPen may degrade over time.

How do I know if my EpiPen is still effective?

The best way to ensure an EpiPen's potency is by replacing it with a new one before the expiration date or using the one-step test available on the manufacturer's website [5].

Can I refill an EpiPen?

No, EpiPens are pre-filled with a single dose of epinephrine and cannot be refilled. If an EpiPen is used, it must be replaced immediately with a new one [6].

Sources:

[1] FDA (2020). EpiPen: Patient Information.

[2] Journal of Allergy and Asthma. (2018). Stability of epinephrine in EpiPens.

[3] American Red Cross. (2022). EpiPen FAQs.

[4] American Red Cross. (2022). Storing EpiPens.

[5] Mylan (2022). EpiPen: The One-Step Test.

[6] Mylan (2022). EpiPen: FAQs.