Avanti polar lipids hspc hydrogenated soy phosphatidylcholine mixture?

Short answer: Avanti Polar Lipids’ HSPC is sold as Hydrogenated Soy Phosphatidylcholine, which is a mixture of saturated phosphatidylcholine species derived from hydrogenated soy PC. It is not a single pure molecular species.

What you should know:
- What it is: A mixture of PC molecules with saturated acyl chains (no double bonds), from hydrogenated soybean PC. The exact fatty-acyl distribution is a batch-dependent mixture and is not published as a single species.
- Why people use it: The high saturation gives a high phase-transition temperature and very stable lipid bilayers, which is useful for robust liposome formulations and long-term stability.
- Common uses in formulations: Often used with cholesterol and PEG-lipids to make stable, long-circulating liposomes. A well-known example formulation uses HSPC:CHOL:PEG-DSPE in roughly 56:38:6 mol% (as used in certain liposomal drugs like Doxil-like systems).
- Exact composition and quality data: For the precise fatty-acyl distribution and purity of a specific lot, check the Certificate of Analysis (COA) or the product data sheet on Avanti’s site for the exact batch you’re considering. If you need help locating it, I can guide you to the right links.
- Practical notes: Store desiccated, typically at -20°C or as recommended by Avanti, and avoid repeated freeze–thaw cycles. This product is for research use only (RUO) unless you have appropriate approvals.

Would you like me to pull up typical COA/data for a specific HSPC lot or compare HSPC to DPPC/DSPC for your liposome design? If you have a target formulation or a project, I can suggest a starting lipid ratio.