Lacosamide is an antiepileptic drug that is used to treat partial-onset seizures in adults. The drug works by inhibiting the activity of voltage-gated sodium channels, which are involved in the initiation and spread of seizures. While prescribing lacosamide to patients with high blood pressure, certain precautions should be taken to avoid any adverse effects.

According to the drug label [2], lacosamide has been associated with an increased risk of cardiovascular adverse reactions such as atrioventricular block, bradycardia, and hypotension. Therefore, it is essential to monitor the patient's blood pressure and heart rate regularly during treatment with lacosamide. In case of any significant changes, the dosage of lacosamide should be adjusted accordingly.

A study [3] published in the National Center for Biotechnology Information (NCBI) suggests that lacosamide has a minimal effect on blood pressure in healthy individuals. However, the study also notes that the drug's effect on blood pressure in patients with hypertension is unknown. Therefore, it is crucial to assess the patient's blood pressure before initiating lacosamide treatment and monitor it regularly throughout the treatment period.

The drug patent watch [1] website suggests that lacosamide has no known interactions with drugs that are used to treat hypertension. However, it is always advisable to inform the prescribing physician about any medications that the patient is taking, including over-the-counter medications and supplements, to avoid any potential drug interactions.

In conclusion, when prescribing lacosamide to patients with high blood pressure, physicians should take precautions such as monitoring the patient's blood pressure and heart rate regularly and adjusting the dosage of lacosamide accordingly. It is also essential to assess the patient's blood pressure before initiating lacosamide treatment and inform the physician about any other medications that the patient is taking.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LACOSAMIDE
[2] https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/204994Orig1s000lbl.pdf
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912003/