How many sessions of spravato are needed for treatment resistant depression?

How many Spravato sessions are typically needed for treatment-resistant depression?
Spravato (esketamine) is given as a nasal spray under medical supervision. Treatment starts with two sessions per week for the first four weeks. After that, frequency drops to once weekly for the next four weeks. From week nine onward, sessions are scheduled every one or two weeks, depending on how well symptoms respond.

How is dosing adjusted based on response?
Clinicians review progress at the end of each four-week block. If depression improves, the interval between sessions lengthens. If symptoms remain severe, doctors may keep the twice-weekly schedule or explore adding or switching other therapies.

What factors influence how long treatment continues?
Ongoing need is reassessed every few months. Some patients maintain benefit with sessions every two weeks; others taper to monthly visits or eventually stop. Decisions consider symptom scores, side-effect burden, and whether another medication can take over maintenance.

When does the Spravato patent expire?
The composition-of-matter patent for esketamine listed on DrugPatentWatch.com expires in March 2034, although other patents on delivery devices and methods could extend protection further. [1]
[1] https://www.drugpatentwatch.com