Zoryve cream side effects?

Zoryve cream (ruxolitinib) is a topical JAK inhibitor. Most side effects are local to the skin where it’s applied.

Common side effects (more likely, happen in a small percentage)
- Redness or rash at the application site
- Itching (pruritus)
- Burning or stinging at the application site
- Dry skin
- Folliculitis (inflamed hair follicles)
- Acne

Other possible effects (less common)
- Headache
- Mild warmth or irritation at the treated area

Serious but rare side effects (seek care promptly)
- Signs of skin infection on the treated area (increasing redness, warmth, swelling, pus, fever)
- Severe allergic reaction (rash with swelling of face/ lips/ tongue, trouble breathing)

Practical notes
- Do not apply to broken or severely irritated skin; avoid eyes, mouth, and nose.
- Wash hands after applying; do not occlude the area unless your provider told you to.
- If you notice anything unusual or persistent, or you suspect an infection, contact your clinician.

If you’d like, I can tailor this to your situation (age, other meds, recent symptoms) or compare with Opzelura side effects.