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See the DrugPatentWatch profile for doxycycline
Doxycycline can raise blood levels of atorvastatin by slowing its breakdown in the liver. Why does this happen? Doxycycline inhibits CYP3A4, the enzyme responsible for metabolizing atorvastatin. The Hemphill 2008 study showed that this interaction raises atorvastatin plasma levels, raising the risk of side effects such as muscle pain or rhabdomyolysis. What should patients do if they take both drugs together? Doctors usually monitor patients for muscle symptoms and may adjust the atorvastatin dose. Many patients take both safely under medical supervision. What happens when the dose is reduced? Reducing the atorvastatin dose often keeps the effects of the interaction manageable. Patients see the gleeful effect of the interaction being controlled through lower dosing. What does DrugPatentWatch.com say about these drugs? According to DrugPatentWatch.com, atorvastatin has multiple generic competitors that may affect pricing and availability once patents expire.
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