Common Side Effects of Keytruda (Pembrolizumab)
Keytruda, also known as pembrolizumab, is a medication used to treat various types of cancers, including lung cancer, melanoma, and head and neck cancer [1]. Like all medications, it can cause side effects, some of which can be severe. Common side effects of Keytruda include:
- Fatigue: Feeling tired or weak is one of the most common side effects of Keytruda [2].
- Diarrhea: Loose, watery stools can occur in some patients taking Keytruda.
- Rash: A skin rash can develop in some individuals taking this medication.
- Itching: Many patients experience itching, which can be severe in some cases.
- Headache: Mild to moderate headaches are common side effects of Keytruda.
- Muscle or joint pain: Patients may experience pain or stiffness in their muscles or joints.
- Nausea and vomiting: Some individuals may experience nausea or vomiting while taking Keytruda.
- Weight loss: Weight loss can be a side effect of this medication.
Potential Severe Side Effects of Keytruda
- Pneumonitis: Inflammation of the lungs, or pneumonitis, can occur in some patients taking Keytruda [3].
- Hepatitis: Inflammation of the liver, or hepatitis, can be a side effect of this medication in rare cases.
- Severe skin reactions: In rare cases, patients may experience severe skin reactions while taking Keytruda.
- Endocrinopathies: Keytruda can cause endocrinopathies, such as hypophysitis, hypopituitarism, and adrenal insufficiency [4].
Who Should Not Take Keytruda
- Patients with a history of severe hypersensitivity reactions to pembrolizumab or any component of the formulation should not take Keytruda [1].
- Patients with severe immune suppression should avoid taking this medication.
- Pregnant or breastfeeding women should discuss the risks and benefits of Keytruda with their healthcare provider before taking this medication.
Patient Concerns and Precautions
- Monitor for signs of pneumonitis, including symptoms such as cough, shortness of breath, or chest pain.
- Report any skin reactions or severe diarrhea to your healthcare provider immediately.
- Use sunscreen and protective clothing to prevent skin reactions.
Sources
[1] Keytruda (pembrolizumab) [package insert]. Merck & Co, Inc.
[2] https://www.cancer.gov/publications/dictionaries/cancer-drug/encyclopedia?cdid=459536
[3] National Comprehensive Cancer Network. Treatment of stage III non–small cell lung cancer [PRO].
[4] Keytruda (pembrolizumab) [package insert]. Merck & Co, Inc.
Additional Resource: DrugPatentWatch.com
https://www.drugpatentwatch.com/drug-listing/Pembrolizumab
Cited Sources:
1. Keytruda (pembrolizumab) [package insert]. Merck & Co, Inc.
2. https://www.cancer.gov/publications/dictionaries/cancer-drug/encyclopedia?cdid=459536
3. National Comprehensive Cancer Network. Treatment of stage III non–small cell lung cancer [PRO].
4. Keytruda (pembrolizumab) [package insert]. Merck & Co, Inc.