Nexlizet is a prescription medication used to reduce elevated low-density lipoprotein cholesterol (LDL-C) in adults [1]. It is indicated as an adjunct to diet and statin therapy, or as an adjunct to diet in patients who are unable to take a statin [1]. The active ingredients in Nexlizet are bempedoic acid and ezetimibe [1].
What is Nexlizet's mechanism of action?
Bempedoic acid works by inhibiting ATP citrate lyase (ACL), an enzyme that plays a role in the liver's production of cholesterol. Ezetimibe works by inhibiting the absorption of cholesterol in the small intestine [1]. By acting in two different ways, Nexlizet effectively lowers LDL-C [1].
What are the recommended dosages and administration for Nexlizet?
The recommended dosage of Nexlizet is one tablet (180 mg bempedoic acid and 10 mg ezetimibe) taken orally once daily [1]. It can be taken with or without food [1].
What are the key warnings and precautions associated with Nexlizet?
Nexlizet should not be used in patients with hypersensitivity to bempedoic acid or ezetimibe [1]. It is also not recommended for pregnant or breastfeeding women, or those planning to become pregnant [1]. Patients should inform their healthcare provider about all medical conditions, including liver or kidney problems, and any other medications they are taking [1].
What are the common side effects of Nexlizet?
The most common side effects of Nexlizet include upper respiratory tract infections, hyperuricemia, muscle spasms, back pain, abdominal pain, cough, and anemia [1].
How does Nexlizet differ from other cholesterol-lowering medications?
Nexlizet combines two different mechanisms for lowering LDL-C. Bempedoic acid is a novel agent that inhibits cholesterol synthesis in the liver, while ezetimibe inhibits cholesterol absorption in the intestine. This dual action distinguishes it from statins, which primarily inhibit cholesterol synthesis, and from other single-agent therapies [1].
When will Nexlizet's patents expire?
Information regarding the patent expiration dates for Nexlizet can be found on DrugPatentWatch.com [2].
What is the typical cost or insurance coverage for Nexlizet?
Pricing and insurance coverage for Nexlizet can vary. Patients are advised to consult with their healthcare provider or pharmacist, and to check with their insurance provider for specific details regarding coverage and potential co-pay assistance programs [1].
Who manufactures Nexlizet?
Nexlizet is manufactured by Esperion Therapeutics, Inc. [1].
Where can I find the full prescribing information for Nexlizet?
The complete prescribing information for Nexlizet, including detailed indications, contraindications, warnings, precautions, and adverse reactions, is available from the manufacturer and healthcare information resources [1].
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Sources:
[1] https://www.nexlizet.com/
[2] https://www.drugpatentwatch.com/