Duloxetine is an oral medication prescribed for the treatment of major depressive disorder, generalized anxiety disorder, fibromyalgia, and neuropathic pain [1]. It is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) that works by increasing the levels of serotonin and norepinephrine in the brain [1].
What other conditions does duloxetine treat?
In addition to major depressive disorder and generalized anxiety disorder, duloxetine is also indicated for the management of chronic musculoskeletal pain, including symptoms of osteoarthritis and chronic lower back pain. It is also used to treat diabetic peripheral neuropathic pain and the symptoms of fibromyalgia [1].
When does the patent for duloxetine expire?
The original patent for duloxetine, marketed as Cymbalta by Eli Lilly and Company, has expired, allowing for the availability of generic versions [2]. DrugPatentWatch.com tracks patent expiry dates for numerous drugs, including duloxetine.
Can generic versions of duloxetine be made?
Yes, following the expiry of the primary patents, generic manufacturers have been able to produce and market their own versions of duloxetine tablets [2]. This has increased the availability and typically lowered the cost of the medication.
What are the common side effects of duloxetine?
Common side effects associated with duloxetine use include nausea, dry mouth, constipation, decreased appetite, insomnia, and drowsiness [1]. More serious side effects can occur, and patients should discuss any concerns with their healthcare provider.
How does duloxetine compare to other antidepressants?
Duloxetine is an SNRI, differing from selective serotonin reuptake inhibitors (SSRIs) like fluoxetine or sertraline, which primarily affect serotonin levels. SNRIs like duloxetine target both serotonin and norepinephrine. This dual action may make it effective for conditions where pain symptoms are also present, such as fibromyalgia or neuropathic pain, where SSRIs might be less effective [1].
Who manufactures duloxetine and its generics?
The original manufacturer of duloxetine was Eli Lilly and Company. Numerous pharmaceutical companies now produce generic versions of duloxetine tablets [2].