Can Lyrica (pregabalin) be taken if you have high or low blood pressure?
Yes, many people take Lyrica (pregabalin) even if they have blood pressure problems, but it can affect blood pressure in some patients. Lyrica is known to cause dizziness and sometimes drowsiness, which can indirectly increase fall risk—especially if you also take blood pressure medicines or already feel lightheaded.
What blood pressure changes can Lyrica cause?
Lyrica can lead to dizziness, and in some cases it may lower blood pressure (or contribute to symptoms that feel like low blood pressure), particularly when starting treatment, increasing the dose, or combining with other medications that affect blood pressure.
If you notice symptoms such as fainting, marked dizziness when standing, unusual weakness, or blurred vision after starting Lyrica or changing the dose, contact your prescriber promptly.
Does Lyrica interact with common blood pressure medications?
There are no universally “unsafe” blood pressure combinations with Lyrica, but using Lyrica alongside antihypertensives can make dizziness more likely. The risk is higher if you:
- start Lyrica at a higher dose,
- recently changed your blood pressure medicine,
- take multiple medicines that affect blood pressure or cause sedation.
Clinicians often start low and titrate slowly to reduce side effects.
What should you do if Lyrica makes you dizzy or lowers your pressure?
If you’re feeling lightheaded or your home blood pressure readings drop, don’t stop Lyrica suddenly without medical advice. Instead:
- sit or lie down if you feel faint,
- stand up slowly,
- check blood pressure (including when standing, if your clinician recommends it),
- ask your prescriber whether the dose should be reduced or timed differently, or whether your blood pressure regimen needs adjustment.
Who needs extra caution?
Extra caution is warranted if you:
- have a history of fainting or orthostatic hypotension (blood pressure drops on standing),
- take several blood pressure or sedating medications,
- have kidney problems (because pregabalin is cleared through the kidneys and dose adjustments may be needed).
Bottom line
Lyrica can be used with blood pressure conditions, but it may worsen dizziness and can contribute to low blood pressure symptoms—especially at the start or after dose increases. If you have dizziness, fainting, or worsening low blood pressure readings, contact your prescriber to review dosing and possible interaction effects.
If you share which blood pressure medication(s) you take and whether your issue is high blood pressure, low blood pressure, or dizziness on standing, I can help you think through the main interaction/safety points to discuss with your clinician.