See the DrugPatentWatch profile for nexletol
What side effects can Nexletol (bempedoic acid) cause?
Common side effects reported with Nexletol include muscle-related complaints such as muscle spasms and pain, plus upper-respiratory symptoms. In clinical use, reports also include gout or increased uric acid levels, and effects that can affect liver enzymes depending on the patient and drug combination. [1]
Why does Nexletol raise gout risk?
Nexletol can increase blood uric acid, which can trigger gout flares in people who already have a history of gout or are prone to high uric acid. If you develop sudden, painful swelling in a joint (often the big toe, ankle, or knee), seek medical advice promptly. [1]
What muscle symptoms should patients watch for?
Patients are advised to watch for new or worsening muscle pain, tenderness, cramps, or weakness. Tell a clinician if symptoms occur, especially if they are severe or come with unusual fatigue or dark-colored urine. [1]
Can Nexletol affect the liver?
As with many cholesterol-lowering medications, clinicians monitor for changes in liver-related lab tests. Patients should report symptoms that can suggest liver problems, such as unusual tiredness, loss of appetite, upper stomach discomfort, dark urine, or yellowing of the skin/eyes. [1]
Are there serious side effects that require urgent care?
Get urgent medical care for signs of a severe allergic reaction, such as trouble breathing, swelling of the face or throat, or hives. Also seek prompt help for severe muscle symptoms or signs of liver injury (yellow skin/eyes, dark urine, severe abdominal pain). [1]
Do side effects change when Nexletol is taken with other cholesterol drugs?
Side effects can depend on the combination regimen. Nexletol is often used with other lipid-lowering therapies, and muscle-related complaints and uric-acid-related problems may be more noticeable in certain patients depending on their baseline risks and the other drugs they take. Your prescribing clinician can tailor monitoring based on your history (especially gout and prior muscle problems). [1]
What should you do if you miss a dose or have symptoms?
If you experience concerning side effects, contact your clinician rather than waiting for the next dose. For missed doses, follow the instructions provided by your pharmacist or prescriber; do not double up unless they tell you to. [1]
Source
- https://www.drugs.com/sfx/nexletol-side-effects.html