How is nivolumab dosed per kilogram in children?

How is nivolumab dosed per kilogram in children

Nivolumab dosing in children is set at 3 mg per kg of body weight. It is given every 2 weeks as a 30-minute infusion. This weight-based approach applies to both pediatric and adult patients who receive solid organ transplants or who are treated for classical Hodgkin lymphoma, melanoma, and other solid tumors.

When does this weight-based dose change to flat dosing

In patients weighing 40 kg or more, many treatment protocols shift from the 3 mg/kg schedule to a flat 240 mg dose given every 2 weeks. The switch happens mainly because pharmacokinetic data show comparable exposure levels between the two method