Does uzedy last 2 months?

Does UZEDY Last 2 Months?

UZEDY (risperidone extended-release injectable suspension) is approved for once-monthly or once-every-two-months subcutaneous dosing in adults with schizophrenia. The 2-month dosing interval (every 8 weeks) uses higher strengths—100 mg or 125 mg—to maintain therapeutic risperidone levels over that period.[1][2]

How Does the 2-Month Dose Work?

It delivers steady risperidone release via a subcutaneous depot, with peak plasma levels around day 7-10 and sustained exposure through week 8. Clinical trials showed equivalent efficacy and safety to monthly dosing, with no significant loss in schizophrenia symptom control.[2][3]

Available Doses and Scheduling

• Monthly: 50 mg, 75 mg, 100 mg, or 125 mg every 4 weeks.
  
• 2-Monthly: 100 mg or 125 mg every 8 weeks (starting after at least two monthly doses).
  Dosing starts monthly to establish tolerance, then switches if tolerated.[1][2]
  
  

What Happens If You Miss a 2-Month Dose?

Administer as soon as possible, then resume every 8 weeks. If delayed over 8 weeks, restart with monthly dosing to rebuild levels. Plasma monitoring may guide adjustments.[2]

Side Effects with Longer Dosing

Common issues like weight gain, somnolence, and injection-site reactions occur similarly to monthly use. Long-acting nature means effects linger if issues arise—prolactin elevation and EPS risks persist.[2][3]

Who Makes UZEDY and When Did It Launch?

Teva Pharmaceuticals and MedinCell developed it. FDA approved in April 2023; 2-month dosing added December 2023.[1][4]

[1]: UZEDY Prescribing Information (Teva)
[2]: FDA Label for UZEDY
[3]: Phase 3 RISE Study (NPJ Schizophrenia)
[4]: Teva Press Release (Dec 2023)