Methotrexate is a medication used to treat various types of cancer and autoimmune diseases such as rheumatoid arthritis and psoriasis. According to the sources provided, there are age-related contraindications for methotrexate use.

The drug patent watch [1] states that methotrexate is contraindicated in patients who are pregnant or breastfeeding, as well as in patients with pre-existing blood disorders, liver disease, or kidney disease. Additionally, it is not recommended for use in children under two years of age.

The National Center for Biotechnology Information [2] mentions that methotrexate should be used with caution in elderly patients, as they may be more susceptible to side effects such as liver and kidney damage. The dosage may need to be adjusted based on the patient's age and overall health.

The FDA label [3] for methotrexate also lists age as a factor to consider when prescribing the medication. It states that the drug should be used with caution in elderly patients, and that dosage adjustments may be necessary.

In summary, methotrexate is contraindicated in pregnant or breastfeeding women, as well as in patients with certain pre-existing conditions. It is not recommended for use in children under two years of age, and caution should be taken when prescribing it to elderly patients. Dosage adjustments may be necessary based on the patient's age and overall health.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/METHOTREXATE
[2] https://www.ncbi.nlm.nih.gov/books/NBK556114/
[3] https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/008085s066lbl.pdf