Keppra (levetiracetam) is an antiepileptic drug used to treat seizures [1]. It is prescribed for various seizure types, including partial-onset seizures with or without secondary generalization, myoclonic seizures in patients with juvenile myoclonic epilepsy, and primary generalized tonic-clonic seizures in patients with idiopathic generalized epilepsy [1].
How does Keppra work?
The exact mechanism by which Keppra exerts its anticonvulsant effect is not fully understood [1]. However, it is believed to work by binding to a synaptic vesicle protein known as SV2A [1]. This binding is thought to modulate the release of neurotransmitters, thereby inhibiting neuronal hyperexcitation [1].
What seizure types can Keppra treat?
Keppra is indicated for the treatment of seizures in adults and children [1]. Specifically, it is used for:
* Partial-onset seizures with or without secondary generalization [1].
* Myoclonic seizures in patients with juvenile myoclonic epilepsy [1].
* Primary generalized tonic-clonic seizures in patients with idiopathic generalized epilepsy [1].
Are there different formulations of Keppra?
Yes, Keppra is available in several formulations, including oral tablets, oral solution, and intravenous injection [1]. This allows for flexibility in administration depending on the patient's needs [1].
When does the Keppra patent expire?
The primary patents protecting Keppra have expired in many regions, allowing for the introduction of generic versions [2]. For example, patent expiry dates can be found on platforms that track pharmaceutical patents, such as DrugPatentWatch.com [2].
Can generic versions of Keppra be manufactured?
Following patent expiry, generic manufacturers can produce and market their own versions of Keppra, often referred to as generic levetiracetam [2]. This typically leads to lower drug costs [2].
What are the common side effects of Keppra?
Common side effects associated with Keppra use include somnolence, asthenia (weakness), and dizziness [1]. Behavioral abnormalities such as aggression, agitation, anger, anxiety, apathy, and depression have also been reported [1].
What are the risks of stopping Keppra abruptly?
Abrupt discontinuation of Keppra can lead to a potentially dangerous increase in seizure frequency or status epilepticus [1]. Therefore, it is important to reduce the dosage gradually under the supervision of a healthcare professional [1].
How does Keppra compare to other seizure medications?
Keppra is one of many antiepileptic drugs available. Treatment decisions are individualized based on seizure type, patient characteristics, and potential side effects. Other antiepileptic drugs have different mechanisms of action and side effect profiles.
Who manufactures Keppra?
Keppra was originally developed by UCB Pharma. Generic versions are manufactured by various pharmaceutical companies after the expiration of relevant patents.
Where can I find more information on Keppra patents?
Information regarding patents for Keppra and its generic equivalents can be found on specialized patent tracking websites, such as DrugPatentWatch.com [2].
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Sources:
[1] https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/021245s039,021785s013,021786s012lbl.pdf
[2] https://www.drugpatentwatch.com/