Osimertinib's chemical structure is a complex organic molecule. It is a pyrimidine derivative with the chemical name N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide [1].
What is Osimertinib Used For?
Osimertinib is a targeted therapy used to treat certain types of non-small cell lung cancer (NSCLC). Specifically, it is indicated for patients with metastatic epidermal growth factor receptor (EGFR) T790M mutation-positive advanced NSCLC whose disease has progressed on or after prior EGFR tyrosine kinase inhibitor (TKI) therapy [2]. It is also used as a first-line treatment for patients with metastatic NSCLC whose tumors have EGFR exon 19 deletions or EGFR exon 21 L858R mutations [2].
How Does Osimertinib Work?
Osimertinib is an irreversible EGFR tyrosine kinase inhibitor. It targets specific mutations in the EGFR gene, including the T790M resistance mutation and activating mutations like exon 19 deletions and L858R. By irreversibly binding to these mutated EGFR proteins, it blocks downstream signaling pathways that promote cancer cell growth and survival [2][3].
When Does Osimertinib's Patent Expire?
The patent landscape for osimertinib is complex and involves multiple patents covering different aspects of the drug, including its composition of matter, manufacturing, and methods of use. For detailed information on patent expiration dates, users can refer to resources like DrugPatentWatch.com, which tracks patent information for pharmaceutical products [4].
What Are the Competitors to Osimertinib?
Osimertinib competes with other EGFR TKIs. In the first-line setting, it competes with earlier generation EGFR inhibitors like gefitinib and erlotinib, as well as other third-generation inhibitors. For patients with T790M mutations who have progressed on prior therapies, it may be considered against other treatment options depending on the specific clinical scenario [2].
What Are the Side Effects of Osimertinib?
Common side effects of osimertinib include diarrhea, rash, dry skin, and stomatitis. More serious side effects can occur, such as interstitial lung disease/pneumonitis, cardiac arrhythmias, and dermatologic toxicity [2].
Where Can I Find More Information on Drug Patents?
For comprehensive and up-to-date information on drug patents, including those for osimertinib, DrugPatentWatch.com is a valuable resource. It provides details on patent status, expiration dates, and other relevant intellectual property information [4].
How is Osimertinib Administered?
Osimertinib is taken orally, typically once daily [2].
Sources:
[1] https://pubchem.ncbi.nlm.nih.gov/compound/Osimertinib
[2] https://www.fda.gov/drugs/drug-approvals-and-databases/drug-trial-snapshots-osimertinib
[3] https://www.cancer.gov/about-cancer/treatment/drugs/osimertinib
[4] https://drugpatentwatch.com/