How do i use miebo?

See the DrugPatentWatch profile for miebo

How to Use Miebo (Mibefradil Ophthalmic Solution 0.005%)

Miebo is a prescription eye drop approved by the FDA in 2023 to treat dry eye disease by increasing tear production. Use it exactly as your doctor prescribes, typically one drop in each affected eye, four times a day. Wash hands before use, tilt head back, pull down lower eyelid, and instill drop without touching the tip to eye or any surface. Blink gently and close eyes for 1-2 minutes afterward. If using other eye drops, wait at least 30 minutes between them.[1][2]

Standard Dosing Schedule

Adults: Instill 1 drop per eye four times daily (about every 4 hours while awake). No pediatric approval. Missed dose: Use as soon as remembered unless close to next dose; do not double up. Store at room temperature, protect from light, discard 2 months after opening.[1][3]

Step-by-Step Application Instructions

1. Shake bottle well before each use.
   
2. Remove cap, avoid touching dropper tip.
   
3. Look up, pull down lower lid to form pocket.
   
4. Squeeze bottle for one drop; do not touch eye.
   
5. Close eye, press inner corner for 1-2 minutes to prevent drainage.
   
6. Replace cap tightly. Use within 12 hours of first opening on that day.[2][4]
   
   

What If I Wear Contact Lenses?

Remove contacts before applying Miebo. Wait 30 minutes before reinserting. Miebo does not contain preservatives, so it's suitable for sensitive eyes but not specifically tested with contacts during wear.[1][3]

Common Mistakes and How to Avoid Them

Do not use more than prescribed—overuse risks irritation. Keep bottle upright to prevent leaks. If dropper touches skin or eye, clean with sterile wipe and consider discarding if contaminated. Refrigerate unopened bottles; do not freeze.[2][4]

Possible Side Effects During Use

Most common: Mild eye discomfort or itching (up to 13% of users). Rare: Corneal issues, blurred vision. Stop use and contact doctor for severe pain, redness, or vision changes. Safe for long-term use in trials up to 16 weeks.[1][3]

Sources
[1]: FDA Miebo Label
[2]: Miebo Prescribing Information - Bausch + Lomb
[3]: Drugs.com - Miebo
[4]: DailyMed - Miebo