Keppra, whose active ingredient is levetiracetam, is an antiepileptic drug used to treat partial-onset seizures, myoclonic seizures, and generalized tonic-clonic seizures [1]. It is also used in combination with other medications to treat infantile spasms [1].
How does Keppra work?
The exact mechanism by which levetiracetam exerts its antiepileptic effect is not fully understood [2]. However, it is known to bind to the synaptic vesicle protein 2A (SV2A) [2]. This protein is found in brain tissue and is thought to modulate the release of neurotransmitters [2].
When did Keppra's patents expire?
The initial patents for Keppra have expired, allowing for the development of generic versions of levetiracetam [3]. Patent expiration dates can vary by region and specific patent, but the compound patent for levetiracetam is no longer in effect in major markets [3]. DrugPatentWatch.com provides detailed patent information for many drugs, including Keppra [3].
What are the generic alternatives to Keppra?
Generic versions of levetiracetam are available from various pharmaceutical companies. These generics are bioequivalent to the brand-name Keppra, meaning they are absorbed and processed by the body in the same way [4].
What are the common side effects of Keppra?
Common side effects of Keppra can include drowsiness, dizziness, and fatigue [1]. Behavioral changes, such as irritability and mood changes, have also been reported [1]. Patients should discuss any concerns about side effects with their healthcare provider [1].
What are the risks associated with stopping Keppra?
Abruptly stopping Keppra can lead to an increase in seizure frequency or status epilepticus, a medical emergency where seizures do not stop [1]. Any changes to medication should be made under the guidance of a healthcare professional [1].