How to Take Emend
Emend (fosaprepitant dimeglumine for injection, followed by aprepitant oral capsules) treats nausea and vomiting from chemotherapy or surgery. It comes as a single-day IV dose on day 1 (115 mg over 15 minutes, 30 minutes before chemo), followed by oral capsules: 80 mg on days 2 and 3.[1]
Always follow your doctor's exact instructions, as dosing depends on your treatment regimen. Swallow capsules whole with water, with or without food. Do not crush or open them.
Dosage by Use Case
Chemotherapy-induced nausea (with dexamethasone and ondansetron):
- Day 1: 115 mg IV Emend + steroids/antiemetics.
- Day 2: 80 mg oral.
- Day 3: 80 mg oral.[1]
Postoperative nausea (adult oral only):
- 40 mg capsule once, within 3 hours before anesthesia.[1]
For kids (6 months+), weight-based IV dosing applies under medical supervision.[1]
Step-by-Step Administration
- Receive IV dose in a clinic 30 minutes before chemo starts.
- Take oral doses at the same time each morning for days 2-3.
- Store capsules at room temperature; discard unused portions after 18 months.[1]
Healthcare providers handle IV; patients self-administer orals.
What If I Miss a Dose?
Take the missed oral dose as soon as you remember, unless it's near the next dose—then skip it. Do not double up. For IV, contact your doctor immediately.[1]
Common Side Effects Patients Report
Fatigue, diarrhea, pain at IV site, hiccups, constipation. Serious risks include allergic reactions or liver issues—seek help for rash, yellowing skin, or severe pain.[1] Report to your doctor.
Interactions and Precautions
Avoid with strong CYP3A4 inhibitors (e.g., ketoconazole) or inducers (e.g., rifampin), as they alter levels. Use caution with warfarin, hormonal birth control, or meds like pimozide. Not for pregnancy unless needed; use backup contraception.[1]
Tell your doctor about liver problems, allergies, or other drugs.
Storage and Availability
Capsules: Room temperature (20-25°C), away from moisture. IV: Refrigerate, use within 24 hours of dilution. Prescription-only; generic aprepitant available.[1]
[1] Emend Prescribing Information (Merck)