How many dupixent injections are in a month?

Standard Dosing for Dupixent

Dupixent (dupilumab) dosing depends on the condition treated, patient age/weight, and whether it's the initial loading dose or maintenance phase. Adults and adolescents (12+ years, 60kg+) typically receive 2 injections in the first month (one 600mg loading dose on day 1, split into two 300mg pre-filled syringes or pens, followed by a second 300mg dose 2 weeks later). After that, it's 2 injections every month (300mg every 2 weeks).[1][2]

Dosing by Condition and Age

• Moderate-to-severe atopic dermatitis (adults/adolescents 12+, ≥60kg): Month 1: Two 300mg injections (day 1 and day 15). Ongoing: Two 300mg every 4 weeks.[2]
  
• Atopic dermatitis (children 6 months-5 years): Weight-based; e.g., 15-30kg get 200mg every 4 weeks (one injection monthly after loading). Total per month: Usually 1 injection.[2]
  
• Asthma (adults/adolescents 12+): Same as above—2 injections monthly (300mg every 2 weeks).[2]
  
• Chronic rhinosinusitis with nasal polyps (adults): 2 injections monthly.[2]
  
• Eosinophilic esophagitis (adults/adolescents 12+, ≥40kg): Initial two 300mg doses (week 1, day 1 and 5), then 1 injection every 2 weeks (600mg, often two 300mg pens).[2]
  
• Prurigo nodularis or COPD (adults): 2 injections monthly.[2]
  
  Pediatric asthma (6-11 years) uses weight-based dosing, often 1-2 injections monthly.[2]
  
  

How It's Packaged and Administered

Each 300mg dose comes as one pre-filled syringe or pen. A monthly supply for standard adult maintenance is two 300mg units (e.g., a carton with two pens). Injections are subcutaneous, self-administered or by a caregiver, every 2 weeks for most regimens. Loading doses ensure quick steady-state levels.[1][3]

Factors Affecting Monthly Injections

• Weight adjustments (e.g., kids <30kg get fewer/half-size doses, often 1 injection monthly).
  
• Missed doses: Take as soon as possible; if >1 week late for every-2-week schedule, skip and resume.
  
• Provider instructions: Always follow personalized prescription; some switch to every-4-week 600mg dosing for certain patients.[2]
  
• Pregnancy/renal issues: No dose changes, but monitor.[2]
  
  

Cost and Supply Considerations

A 4-week supply for adults (two 300mg pens) costs $3,000-$5,000 list price before insurance/copay cards. Patient assistance programs like Dupixent MyWay cover eligible patients.[3]

[1]: Dupixent.com prescribing information
[2]: FDA label for Dupixent
[3]: Drugs.com - Dupixent dosing