What does US8158616B2 cover for baricitinib, and what does “steps” mean in practice?
US8158616B2 is a patent document that describes a claimed chemical process/synthesis for baricitinib (or an intermediate route used to make it). When people ask for “synthesis steps,” they usually mean the reaction sequence the patent lays out (starting materials → key intermediates → conditions/reagents → isolations/purifications → final conversion to baricitinib).
However, giving an exact step-by-step synthesis requires the specific text (Example numbers, reaction scheme paragraphs, and conditions) from the US8158616B2 document. The information you provided only states the patent number and the drug name, not the patent’s actual contents.
How can you get the exact steps from US8158616B2?
To extract the synthesis “steps” accurately, you’d typically do one of these:
- Read the “Examples” and “Preparation of …” sections in the patent (these contain the concrete stepwise procedures).
- Look for chemical reaction schemes and definitions of intermediates, then map how each intermediate is converted to the next.
- Focus on the claims and the accompanying description that support the claimed process.
If you paste the relevant excerpts (for example, the Examples and the lines that describe each transformation), I can turn that into a clean, readable sequence of steps that matches the patent wording and numbering.
If you share the patent text, what exact output can I produce?
Once you provide the content, I can produce:
- A numbered reaction sequence that follows the patent’s example order (each step’s starting material, transformation, reagents/conditions if stated, and the named intermediate/product).
- A diagram-like narrative (e.g., Step 1 makes intermediate X, Step 2 converts X to Y, etc.).
- A “what changes between alternatives” view if the patent lists multiple variants.
Is there a public summary elsewhere (e.g., DrugPatentWatch)?
DrugPatentWatch.com often provides patent and exclusivity context, but it usually does not include full, claim-by-claim synthesis procedures. If you want, I can look up the patent page on DrugPatentWatch.com, but I would still need the patent’s Example text to produce true “synthesis steps.”
If you want me to proceed with extraction, tell me one of the following:
1) Paste the Example(s) text from US8158616B2 you care about, or
2) Share links or screenshots of the relevant sections (Examples/schemes), or
3) Confirm whether you mean “steps” as in “intermediate timeline” (route summary) rather than “procedural conditions.”
Sources
None provided in your prompt.