Can you take Lyrica (pregabalin) with losartan?
Yes, Lyrica (pregabalin) and losartan are commonly prescribed together, and there is no well-known direct interaction that would automatically make the combination unsafe.
What do clinicians watch for if you use them together?
Even without a specific drug–drug interaction, the combination can matter because both can affect how you feel day to day:
- Dizziness and low blood pressure: Losartan lowers blood pressure. Lyrica can cause dizziness and sleepiness. Together, this can raise the chance of feeling lightheaded—especially when you first start either medicine, increase a dose, or stand up quickly.
- Falls risk: If you get sleepy or dizzy on Lyrica, taking it while also lowering blood pressure with losartan can increase fall risk in some people.
What side effects should prompt you to get medical advice?
Contact a clinician promptly (or seek urgent care if severe) if you develop:
- Fainting or near-fainting
- Severe dizziness or worsening imbalance
- Chest pain, shortness of breath, or unusual weakness
Can the doses need adjustment?
Sometimes. If you start Lyrica or change doses, or if your losartan dose changes, your prescriber may want to monitor:
- Blood pressure, especially the first few days to weeks
- Symptoms like dizziness, sedation, or falls risk
- Kidney function and overall tolerance (particularly in older adults or people with kidney issues)
Practical safety tips
- Avoid alcohol and other sedating medicines when starting Lyrica or increasing the dose, because they can worsen sleepiness/dizziness.
- Stand up slowly from sitting or lying down.
- If you feel dizzy, don’t drive or operate machinery until you know how the medicines affect you.
What to do if your prescriber is unsure
If you tell your prescriber or pharmacist:
- your exact doses
- your age
- any history of low blood pressure, fainting, kidney disease, or falls
they can advise the safest starting plan and whether monitoring is needed.
If you share your Lyrica dose (mg) and losartan dose (mg), plus any other meds you take, I can point out the most likely tolerance issues to watch for.