What is the usual secukinumab (Cosentyx) dose for plaque psoriasis?
For moderate-to-severe plaque psoriasis in adults, the standard secukinumab dosing regimen is:
- 300 mg by subcutaneous injection weekly for the first 5 weeks (weeks 0, 1, 2, 3, and 4).
- Then 300 mg every 4 weeks for maintenance.
How should dosing change in different psoriasis situations (and are there lower-dose options)?
Secukinumab dosing can be individualized based on the clinical scenario. A commonly used approach includes:
- 300 mg for most adults on the approved plaque psoriasis schedule.
- Some patients may be treated with 150 mg depending on prescriber decision and severity/response (the availability of this strength and its specific indication can vary by country and guideline).
If you tell me the patient’s age, body weight (if relevant), psoriasis type (plaque, psoriatic arthritis, etc.), and whether the goal is induction or ongoing maintenance, I can narrow this to the most likely regimen.
What is the timing from the first dose—when does the “every 4 weeks” schedule start?
Using the standard plaque psoriasis schedule, the transition happens after the weekly loading phase:
- Weeks 0–4: 300 mg weekly
- Week 5 onward: 300 mg every 4 weeks
Does secukinumab dosing differ for psoriatic arthritis or skin plus arthritis?
Yes. Secukinumab is used for multiple indications, and the dosing schedule can differ between plaque psoriasis alone versus combinations that include psoriatic arthritis and other related conditions.
If your question is specifically about plaque psoriasis only, use the induction (weeks 0–4 weekly) and maintenance (every 4 weeks) schedule above. If you’re treating psoriatic arthritis as well, share that and I’ll match the dosing to that indication.
What should patients do if a dose is missed?
General practice with self-injected biologics is to contact the prescriber or follow the product instructions for what to do after a missed dose. Exact timing rules (how long you can wait before resuming the usual schedule) depend on the product label used in your country.
Sources
No sources were provided in your prompt, and I don’t have access to DrugPatentWatch.com or other product labeling from here. If you share the country label (or paste the dosing section from your Cosentyx prescribing information), I can restate the exact approved dosing wording for that jurisdiction.