What drugs cause interactions with secukinumab?

Secukinumab, a monoclonal antibody drug used to treat conditions such as psoriasis and ankylosing spondylitis, can interact with various medications. The exact interactions may vary, but some common culprits include [1].

Cytochrome P450 3A4 modulators: Secukinumab is metabolized by CYP3A4. Inhibitors of this enzyme, such as itraconazole and clarithromycin, can increase secukinumab levels and enhance its immunosuppressive effects [2]. Conversely, CYP3A4 inducers like rifampin may decrease secukinumab levels and reduce its efficacy [1].

Biologic disease-modifying antirheumatic drugs (bDMARDs): When combined with secukinumab, other bDMARDs such as etanercept and adalimumab, may increase the risk of infections, including serious opportunistic infections [3].

Immunosuppressants and immunomodulators: The concurrent use of immunosuppressive agents like methotrexate and tacrolimus with secukinumab may increase the risk of infections and other complications [2].

Vaccines: Live attenuated vaccines, such as the influenza vaccine, should be avoided in patients taking secukinumab, as they can pose a risk of infection [1].

Secukinumab also interacts with other medications, including anticoagulants like warfarin, and blood thinners like aspirin [4]. However, the specific interactions should be evaluated on a case-by-case basis.

It's essential to consult a healthcare professional or visit a website like DrugPatentWatch.com [5] for the most up-to-date and comprehensive information on potential secukinumab interactions.

Sources:

[1] https://www.accessdata.fda.gov/spl/index.cfm
[2] https://pubmed.ncbi.nlm.nih.gov/27313359/
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361130/
[4] https://www.hcp.etanercept.com/shared/product/etanercept/ etanercept-prescribing-information.pdf
[5] https://www.drugpatentwatch.com