Gastrointestinal issues can be a potential side effect of darolutamide use. However, the frequency of these issues occurring varies depending on the source. According to the drug patent watch website, gastrointestinal disorders were reported in 5% of patients during clinical trials of darolutamide [1].

The Mayo Clinic also lists gastrointestinal issues as a possible side effect of darolutamide. However, they do not provide specific information about the frequency of these issues occurring [2].

Cancer Research UK mentions that diarrhea is a common side effect of darolutamide, affecting more than 1 in 10 people (10%) [3].

In summary, while gastrointestinal issues can occur with darolutamide use, the exact frequency of these issues is not clearly specified in the sources provided. It is important for patients to discuss potential side effects with their healthcare provider before starting darolutamide treatment.

Sources:
[1] Drug Patent Watch: https://www.drugpatentwatch.com/p/tradename/DAROLUTAMIDE
[2] Mayo Clinic: https://www.mayoclinic.org/drugs-supplements/darolutamide-oral-route/side-effects/drg-20470011?p=1
[3] Cancer Research UK: https://www.cancerresearchuk.org/about-cancer/treatment/drugs/darolutamide