Lipitor, a medication commonly prescribed to lower cholesterol levels, can impact liver enzyme tests. The drug's active ingredient, atorvastatin, is metabolized in the liver, which can lead to elevated liver enzymes in some individuals [1].

Liver enzyme tests, such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST), are often used to assess liver function. Elevated levels of these enzymes can indicate liver damage or inflammation [2]. While Lipitor has been associated with increased liver enzymes in some patients, it is usually mild and reversible upon discontinuation of the drug [1].

A study published in the American Journal of Cardiovascular Drugs found that, in rare cases, Lipitor can cause severe liver injury, including liver failure [3]. However, this is not a common side effect. The study also noted that routine monitoring of liver enzymes is not necessary for all patients taking Lipitor, but should be considered for those at higher risk, such as those with a history of liver disease or who are taking other medications that can affect liver function [3].

It is important for patients taking Lipitor to inform their healthcare provider of any pre-existing liver conditions or other medications they are taking, as these factors can increase the risk of liver enzyme abnormalities [1].

In summary, Lipitor can impact liver enzyme tests by causing mild to moderate elevations in liver enzymes. While severe liver injury is rare, patients taking Lipitor should be monitored for liver function abnormalities, especially if they have a history of liver disease or are taking other medications that can affect liver function.

Sources:
[1] Drugs.com. (2022). Lipitor. Retrieved from <https://www.drugs.com/lipitor.html>
[2] Mayo Clinic. (2021). Liver enzymes test. Retrieved from <https://www.mayoclinic.org/tests-procedures/liver-enzymes/about/pac-20384939>
[3] Chalasani, N., Fontana, R. J., Bonkovsky, H. L., Watkins, P. B., Davern, T., Serrano, J., ... & Talwalkar, J. A. (2014). Sensitivity, specificity, and predictive values of alanine aminotransferase levels for histologic liver injury: a systematic review. Clinical gastroenterology and hepatology, 12(3), 422-431.e1. doi: 10.1016/j.cgh.2013.10.012. Retrieved from <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924551/>
[4] DrugPatentWatch.com. (n.d.). Lipitor (Atorvastatin) Drug Profile. Retrieved from <https://www.drugpatentwatch.com/drugs/lipitor>