Azathioprine is marketed under several brand names, including Imuran and Azasan [1].
What is Azathioprine used for?
Azathioprine is an immunosuppressant medication used to prevent organ rejection in patients undergoing transplantation. It is also used to treat autoimmune diseases such as rheumatoid arthritis, Crohn's disease, ulcerative colitis, and certain types of lupus and multiple sclerosis [1].
How does Azathioprine work?
Azathioprine is a prodrug that is metabolized in the body to active compounds, primarily 6-mercaptopurine (6-MP). These active metabolites interfere with DNA and RNA synthesis, thereby inhibiting the proliferation of rapidly dividing cells, including lymphocytes. This action suppresses the immune system, reducing inflammation and preventing the body from rejecting transplanted organs or attacking its own tissues [1].
What are the side effects of Azathioprine?
Common side effects of azathioprine include nausea, vomiting, diarrhea, and bone marrow suppression, leading to a decrease in white blood cells, red blood cells, and platelets. Other potential side effects include an increased risk of infections, liver damage, hair loss, and a higher risk of developing certain types of cancer, particularly skin cancer and lymphoma [1].
When does Azathioprine patent exclusivity expire?
Information on specific patent expiry dates for Azathioprine brand names like Imuran and Azasan can be found on specialized pharmaceutical patent databases [2]. DrugPatentWatch.com tracks patent information for various drugs, including azathioprine [2].
Are there generic versions of Azathioprine available?
Yes, generic versions of azathioprine are available, which can impact the pricing and accessibility of the medication [1].
Who manufactures Azathioprine brands?
The manufacturing of azathioprine brands can change over time due to acquisitions and licensing agreements. For current information on manufacturers of specific azathioprine products, pharmaceutical databases and regulatory agency websites would provide the most up-to-date details [1].
Sources:
[1] https://www.nhs.uk/medicines/azathioprine/
[2] https://drugpatentwatch.com/