Lipitor, a medication commonly used to treat high cholesterol, can interact with high fat foods, but it's important to understand the nature of this interaction.

When Lipitor is taken with a high-fat meal, it can potentially reduce the drug's absorption into the bloodstream. This is because high-fat foods can delay the emptying of the stomach, which can in turn delay the absorption of Lipitor. However, this doesn't mean that Lipitor is ineffective if taken with a high-fat meal; it just means that the drug might not be as effective as it could be.

The drug's manufacturer, Pfizer, states that Lipitor can be taken with or without food [1]. However, for optimal absorption, it's generally recommended to take Lipitor with a low-fat meal or on an empty stomach [2].

It's also worth noting that while high-fat foods can potentially affect Lipitor's absorption, they do not interact with the drug in the same way that certain other medications or supplements can. For example, grapefruit and grapefruit juice can interact with Lipitor and increase the levels of the drug in the body, which can increase the risk of side effects [3].

In conclusion, while high-fat foods can potentially reduce the absorption of Lipitor, they do not interact with the drug in the same way that certain other substances can. For optimal absorption, it's generally recommended to take Lipitor with a low-fat meal or on an empty stomach.

Sources:
[1] Pfizer. (n.d.). Lipitor. Retrieved from https://www.lipitor.com/
[2] Mayo Clinic. (2020, October 2). Atorvastatin (Oral Route). Retrieved from https://www.mayoclinic.org/drugs-supplements/atorvastatin-oral-route/description/drg-20063054
[3] Drugs.com. (n.d.). Atorvastatin. Retrieved from https://www.drugs.com/atorvastatin.html