What is Dexlansoprazole Used For?
Dexlansoprazole is a proton pump inhibitor (PPI) used to treat symptoms associated with acid reflux. It is prescribed to heal erosive esophagitis and maintain healing in patients who have been treated for it. It also helps manage heartburn associated with symptomatic gastroesophageal reflux disease (GERD) [1].
How Does Dexlansoprazole Work?
Dexlansoprazole works by reducing the amount of acid produced in the stomach [1]. It does this by irreversibly blocking the H+/K+-ATPase enzyme system, also known as the proton pump, in gastric parietal cells. This action decreases intragastric acidity [2].
How is Dexlansoprazole Different from Other Acid Reducers?
Dexlansoprazole has a unique dual delayed-release formulation. This means it releases medication in two phases, which allows for a prolonged therapeutic effect and can help provide symptom relief throughout a 24-hour period [2]. This formulation may differentiate it from other PPIs that have different release mechanisms.
When Can I Expect Dexlansoprazole to Start Working?
Most patients experience relief from heartburn symptoms within 24 hours of taking dexlansoprazole. Healing of erosive esophagitis typically occurs within 4 to 8 weeks of treatment [1].
What Are the Potential Side Effects of Dexlansoprazole?
Common side effects reported with dexlansoprazole include diarrhea, nausea, headache, and abdominal pain [1].
Are There Risks Associated with Long-Term Dexlansoprazole Use?
Long-term use of proton pump inhibitors, including dexlansoprazole, has been associated with an increased risk of certain conditions. These include bone fractures, particularly of the hip, wrist, or spine, and microscopic colitis. There is also a potential for vitamin B12 deficiency [1].
What Happens if I Miss a Dose of Dexlansoprazole?
If a dose of dexlansoprazole is missed, it should be taken as soon as possible. However, if it is close to the time for the next scheduled dose, the missed dose should be skipped, and the regular dosing schedule should be resumed [1].
Can Dexlansoprazole Interact with Other Medications?
Yes, dexlansoprazole can interact with other medications. It may affect the absorption of drugs that require an acidic environment for absorption, such as ketoconazole, itraconazole, and certain HIV medications. It is important to inform a doctor about all medications being taken, including over-the-counter drugs and herbal supplements [1].
What is the Typical Cost of Dexlansoprazole?
The cost of dexlansoprazole can vary depending on the dosage, quantity, and insurance coverage. Without insurance, the retail price for a 30-day supply can be several hundred dollars. Prescription assistance programs and coupons may be available to help reduce costs [1].
When Does Dexlansoprazole's Patent Protection End?
Information regarding specific patent expiry dates for dexlansoprazole can be found through patent tracking resources [3].
Who Manufactures Dexlansoprazole?
Dexlansoprazole is manufactured by Takeda Pharmaceuticals U.S.A., Inc. [1].
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Sources:
[1] https://www.drugguide.com/ddis/dexlansoprazole
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886029/
[3] https://drugpatentwatch.com/