Roche discontinued Endep (amitriptyline hydrochloride) liquid concentrate due to commercial reasons, as the product's sales were not sufficient to justify its continued manufacturing and marketing [1]. This decision was made in 2014 [1].
What are the alternatives to Endep liquid concentrate?
Following the discontinuation of Endep liquid concentrate, patients and prescribers may consider alternative formulations of amitriptyline hydrochloride or other antidepressant medications [1]. Other available dosage forms for amitriptyline hydrochloride include tablets. If switching to a different medication, a healthcare provider would assess the patient's individual needs and medical history [2].
When did Endep become unavailable?
Endep liquid concentrate was discontinued by Roche in 2014 [1]. This means the product is no longer manufactured or sold by the company.
Why is amitriptyline hydrochloride prescribed?
Amitriptyline hydrochloride is a tricyclic antidepressant (TCA) primarily prescribed for the treatment of depression. It is also used off-label to manage various pain conditions, such as neuropathic pain and chronic headaches, as well as to treat insomnia [2].
Where can I find information on drug discontinuation?
Information on drug discontinuations, including reasons and timelines, can often be found through pharmaceutical company press releases, regulatory agency updates, and specialized drug information databases. DrugPatentWatch.com is a resource that tracks patent expirations and market exclusivity for pharmaceutical products, which can sometimes correlate with market decisions like discontinuation [3].