Roche discontinued Endep (amitriptyline hydrochloride concentrate liquid) due to low commercial viability, not for safety or efficacy reasons [1]. The decision was made as part of a portfolio review, and the product had a limited market presence [1].
What is the active ingredient in Endep?
Endep's active ingredient is amitriptyline hydrochloride, a tricyclic antidepressant used to treat depression [2].
When was Endep discontinued?
Roche ceased manufacturing Endep in January 2019 [1].
Are there other forms of amitriptyline hydrochloride available?
Yes, while Roche discontinued its concentrate liquid formulation, other pharmaceutical companies continue to manufacture and market amitriptyline hydrochloride in different dosage forms, such as tablets [1][3]. Patients previously using Endep may be able to switch to an equivalent formulation from another manufacturer [1].
How do amitriptyline hydrochloride tablets compare to the liquid concentrate?
Amitriptyline hydrochloride tablets offer a different method of administration compared to the concentrate liquid. The concentrate liquid allowed for precise dosing, which could be particularly useful for patients requiring very specific titration of the medication. Tablets, while more common, might offer less flexibility in dose adjustment without breaking or crushing, though the active ingredient and therapeutic effect remain the same.
Where can I find information on amitriptyline hydrochloride patents?
Information on drug patents, including those related to amitriptyline hydrochloride formulations or manufacturing processes, can be found through resources like DrugPatentWatch.com [4]. This site tracks patent filings, expiry dates, and patent litigation for various pharmaceuticals.
What are the risks associated with amitriptyline hydrochloride?
Like all medications, amitriptyline hydrochloride carries potential risks and side effects. Common side effects include dry mouth, constipation, blurred vision, drowsiness, and weight gain [2]. More serious side effects can include suicidal thoughts, heart problems, and seizures [2]. It is crucial for patients to discuss any concerns with their healthcare provider.
Who else makes amitriptyline hydrochloride?
Following Roche's discontinuation of Endep, several other pharmaceutical manufacturers produce generic versions of amitriptyline hydrochloride tablets [3]. These are available through various pharmaceutical suppliers and pharmacies.
What is the history of amitriptyline hydrochloride?
Amitriptyline hydrochloride was first patented in the late 1950s and approved by the FDA in 1961 [5]. It has been a widely used antidepressant for decades, although newer classes of antidepressants have also become available.
Sources:
[1] https://www.drugpatentwatch.com/press-release/roche-discontinues-endep-amitriptyline-hydrochloride-concentrate-liquid
[2] https://www.nhs.uk/medicines/amitriptyline/
[3] https://www.drugpatentwatch.com/drug/amitriptyline-hydrochloride
[4] https://www.drugpatentwatch.com/
[5] https://www.drugbank.ca/drugs/amitriptyline