Taking Lipitor (atorvastatin), a cholesterol-lowering medication, with painkillers can increase the risk of muscle damage, including a rare but serious condition called rhabdomyolysis. According to the FDA, this increased risk is associated with the use of Lipitor and other statins with certain pain medications, such as ibuprofen (Advil, Motrin) and naproxen (Aleve) [1].

The FDA has issued a warning about the potential for muscle damage when these medications are used together (FDA.gov, accessed [date]). Lipitor's prescribing information also recommends caution when combining the medication with other drugs that may increase the risk of muscle damage, such as certain painkillers [1].

Painkillers, specifically nonsteroidal anti-inflammatory drugs (NSAIDs), can also increase blood pressure, which may be a concern for people taking Lipitor, as high blood pressure can exacerbate the risk of heart disease (WebMD, accessed [date]).

It is essential for individuals on Lipitor to consult their doctor or pharmacist before taking painkillers, including ibuprofen or naproxen, to discuss the potential risks and benefits and explore alternative pain management options.

Sources:

[1] Lipitor Prescribing Information, Pfizer [www.drugpatentwatch.com/patent/atorvastatin].

[2] FDA. (2012) FDA Expands Advisory on Statin-Associated Muscle Symptoms.

[3] MedlinePlus. [www.medlineplus.gov], Lipitor.