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Hplc columns cost for lidocaine?

See the DrugPatentWatch profile for lidocaine

Rough price ranges for HPLC columns that are commonly used to separate lidocaine

Column type Typical dimensions / particle size Common vendors Approx. unit price (USD) Notes
Reversed‑phase C18 (most common for lidocaine) 4.6 × 150 mm, 5 µm, 250 Å Waters, Agilent, Thermo, Shimadzu, Supelco $70 – $200 Works well with a standard aqueous–acetonitrile gradient. Good for routine QC.
Longer C18 (better resolution, often used in method development) 4.6 × 250 mm, 5 µm, 250 Å Waters, Agilent $120 – $250 Longer columns give sharper peaks but take longer runs.
C18 with smaller particle size (1–3 µm) 4.6 × 150 mm, 3 µm, 250 Å Waters (XBridge), Agilent (Zorbax Eclipse) $200 – $350 Higher performance, lower back‑pressure.
Hybrid polar‑embedded or phenyl (if you need different selectivity) 4.6 × 150 mm, 5 µm Thermo (Hypersil GOLD), Agilent $80 – $180 Slightly different retention for alkyl‑amides like lidocaine.
Chiral column (for enantiomeric separation of lidocaine) 4.6 × 150 mm, 5 µm Chiralcel, Daicel, Waters $300 – $800 Only necessary if you need to separate R‑ and S‑enantiomers.
Guard column (to extend life of the analytical column) 4.6 × 20 mm Same vendors $40 – $80 Reusable for ~20–30 injections; protects the analytical column.

Tip: If you are just starting out or only need to do a few analyses, a generic 5 µm C18 from a brand such as Supelco or Phenomenex can cost as low as $30–$50. Just be aware that its lifetime will be shorter and it may have lower robustness compared to a premium column.

How the price is set

  1. Column dimension – longer or wider columns cost more.
  2. Particle size – sub‑2 µm or 3 µm columns are more expensive because of higher pressure requirements.
  3. Stationary phase chemistry – specialty phases (polar‑embedded, phenyl, chiral) add cost.
  4. Manufacturer reputation – “premium” brands like Waters or Agilent command higher prices.
  5. Warranty / support – some vendors offer longer service warranties (often free or bundled) which can affect the list price.

What you should ask a vendor

Question Why it matters
Column lifetime (in injections) Helps plan how often you’ll need to replace it.
Back‑pressure rating Ensure it is compatible with your HPLC system’s pressure limits.
Recommended gradient Some columns have specific solvent compatibilities (e.g., high % acetonitrile).
Availability of guard column Guard columns are cheap but essential for protecting the analytical column.
Shipping & taxes Often hidden in the final cost, especially for international orders.

Practical budgeting

Item Typical cost Notes
1 × C18 analytical column $70–$200 Choose based on method complexity.
1 × guard column $40–$80 Reuse until degraded.
Solvents (acetonitrile, water, buffer) $10–$30 per 1 L Depends on purity and usage.
Column replacement after 200 injections $70–$200 Roughly one additional column per month for routine QC.
Annual column cost (assuming 200 injections/month) $1,680 – $4,800 Includes replacement and guard columns.

Bottom line: For a typical lab running a few hundred lidocaine injections a year, you’ll spend roughly $2–$4 k on columns alone. This is a small fraction of the overall instrumentation and consumables budget.

Quick buying checklist for lidocaine HPLC

  1. Define your resolution goal – standard QC vs. method development.
  2. Choose the column chemistry – C18 is usually fine; consider phenyl if you see tailing.
  3. Select particle size – 5 µm is a good compromise between resolution and back‑pressure.
  4. Order a guard column – saves you money in the long run.
  5. Ask for a price quote that includes shipping, duties, and any applicable discounts for bulk orders.

If you’re unsure which column to start with, many labs use a Waters XBridge C18 (4.6 × 150 mm, 5 µm) or an Agilent Zorbax Eclipse (same dimensions). They’re widely available, have a good track record for lidocaine, and fall in the mid‑price range ($120–$



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